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Mary Wohltmann Selected Research

Calcium-Independent Phospholipases A2

9/2012Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice.
2/2012Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.
1/2012Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents.
10/2010Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
6/2010Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.
2/2008Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.
2/2008Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations.
7/2006Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.

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Mary Wohltmann Research Topics

Disease

6Insulinoma
05/2014 - 07/2006
3Glucose Intolerance
10/2020 - 07/2006
2Inflammation (Inflammations)
10/2016 - 01/2012
2Diabetes Mellitus
05/2014 - 01/2012
2Dystonia (Limb Dystonia)
09/2012 - 11/2010
2Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile)
09/2012 - 02/2008
2Parkinsonian Disorders (Parkinsonism)
09/2012 - 11/2010
2Hyperglycemia
07/2006 - 01/2002
1Ileitis
12/2021
1Atherosclerosis
10/2020
1Hypercholesterolemia
10/2020
1Insulin Resistance
06/2010
1Obesity
06/2010
1Body Weight (Weight, Body)
06/2010
1Virus Diseases (Viral Diseases)
07/2005

Drug/Important Bio-Agent (IBA)

8Calcium-Independent Phospholipases A2IBA
09/2012 - 07/2006
6Insulin (Novolin)FDA Link
05/2014 - 01/2002
3Glucose (Dextrose)FDA LinkGeneric
10/2020 - 02/2008
3Phospholipases (Phospholipase)IBA
01/2012 - 07/2006
2CholesterolIBA
10/2020 - 06/2010
2Phospholipases A2 (Phospholipase A2)IBA
10/2016 - 06/2010
2Arachidonic Acid (Vitamin F)IBA
10/2016 - 02/2012
2Streptozocin (Streptozotocin)FDA Link
01/2012 - 07/2006
2IronIBA
11/2010 - 02/2008
2Proteins (Proteins, Gene)FDA Link
10/2010 - 07/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2021
1LysophospholipidsIBA
10/2016
1EicosanoidsIBA
10/2016
1Transcription Factor CHOPIBA
05/2014
1Activating Transcription Factor 4IBA
05/2014
1Nonesterified Fatty Acids (NEFA)IBA
05/2014
1PalmitatesIBA
05/2014
1Caspase 3 (Caspase-3)IBA
05/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2014
1CeramidesIBA
05/2014
1p38 Mitogen-Activated Protein KinasesIBA
02/2012
1Oxidants (Oxidizing Agents)IBA
01/2012
1tert-ButylhydroperoxideIBA
01/2012
1CytokinesIBA
01/2012
1EnzymesIBA
11/2010
1Calcium-Calmodulin-Dependent Protein KinasesIBA
10/2010
1Dietary Fats (Dietary Fat)IBA
06/2010
1CarbohydratesIBA
06/2010
1Ubiquitinated ProteinsIBA
02/2008
1Blood Glucose (Blood Sugar)IBA
07/2006
1Biological ProductsIBA
07/2006
1Protein Isoforms (Isoforms)IBA
07/2005
1Messenger RNA (mRNA)IBA
07/2005
1Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA
07/2005